Overpromoted Cholesterol Drugs

The New York Time

Published: April 2, 2008

The news keeps getting worse for two heavily promoted cholesterol drugs, Vytorin and Zetia. These drugs were supposed to offer a valuable alternative to the older cholesterol- lowering agents known as statins, a class that includes Lipitor, Zocor and other drugs that not only reduce cholesterol but also reduce the risk of heart attacks. In clinical trial results released this week, the newer drugs failed to reach their main goal: slowing the growth of artery-clogging plaques ? a suggestion that they might not help ward off heart attacks.

It is distressingly late to be learning that these drugs may provide little or no benefit. They were approved on the basis of evidence that they reduce the level of so-called bad cholesterol in the blood. That data was taken as presumptive evidence that the drugs would reduce heart-attack risks. Despite this slim supporting data, vigorous promotion propelled them to combined sales of more than $5 billion last year, placing them among the world抯 top-selling drugs.

An analysis in the New England Journal of Medicine found that the drugs captured 15.2 percent of the cholesterol- lowering market in this country, driven by an advertising campaign aimed at consumers and aggressive marketing to doctors. But they claimed only 3.4 percent of the market in Canada, where advertising to consumers is prohibited, Vytorin is unavailable and public programs restrict usage. These are drugs that became blockbusters thanks to marketing muscle, not scientific proof of effectiveness.

There are also justifiable concerns that Merck and Schering-Plough, the companies that make the drugs, may have sat on adverse data for more than a year lest their sales be undermined. In e-mail messages unearthed by Senate investigators, the lead scientist on the study warned that repeated delays in releasing the results made it look as if the company was trying to hide something.

In the clinical trial, 720 European patients with genes that cause abnormally high cholesterol levels were given either Vytorin, a combination pill that contains both Zetia and Zocor, or simply Zocor alone. As expected, the combination pill proved better than the statin alone at reducing the level of bad cholesterol. But to everyone’s surprise, Vytorin failed to slow the growth of fatty plaques in the arteries, and it may have even allowed greater growth than the statin did.

Vytorin and Zetia are clearly down, but not necessarily out. It remains possible, for example, that the reason Vytorin had little effect in reducing plaque was that most of these patients had been taking statins for years and their plaque had already been depleted to the point that Vytorin had little room to improve the situation. It is also possible, however, that Vytorin and Zetia are simply less effective than the statins. Other trials now under way may clarify Vytorin’s value in coming years. Meanwhile, heart experts are surely right that Vytorin and Zetia should be a last resort for patients who can’t get their cholesterol down any other way.

On the O’Reilly show on April 1^st  night, Barbara Walters was promoting “staying young and living to 100+”. Resveratrol was the first thing she suggest among her list of things to  do to attain the goal.

What is this Resveratrol?

Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume, or more importantly, an extract found in red wine, resveratrol. Resveratrol is an ingredient with incredible clinical research revealing that it supports cardiovascular and normal cell health. Because wine is so highly processed, the actual amount of resveratrol is quite low. One would have to drink at least three bottles of red wine a day to experience the effects of resveratrol extract. Additionally, the content of resveratrol in red wine is inconsistent and varies by type of wine, region and processing techniques. Resveratrol extract or more specifically, Resveravine®, which is a more concentrated form of resveratrol, ensures that the body reaps all of the benefits of resveratrol, without the ill effects from three bottles of wine.*

Where to get and how is this product unique?

Isotonix® Resveratrol is an isotonic-capable supplement, made from three patented ingredients, Resveravine® with 20% resveratrol extract, BioVin® Advanced with 5% resveratrol extract, and VitaBlue® (wild blueberry extract), designed to promote normal cell health. Isotonix Resveratrol works to maintain cell health, promote normal cell cycle activity, promote apoptosis (programmed cell death) in unhealthy cells, support the normal activity of the SIRT-1 gene, and promote cardiovascular health, by promoting healthy platelet activity, promoting vasorelaxation, and providing antioxidant protection of LDL particles. Resveravine® is a combination of trans-resveratrol (20% purity) and ?-viniferin extracted from vine stems, which work synergistically to enhance the effectiveness of resveratrol extract. Trans-resveratrol is the predominate isomer found in red wine grapes and juice, and Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products from grape skin. According to the Linus Pauling Institute at Oregon State University, trans-resveratrol may have a higher bioavailability than other isomers of resveratrol. Resveravine provides a higher level of free radical defense against oxidative stress, stronger promotion of normal cellular activity, and higher antioxidant protection of LDL particles than pure resveratrol extract.*

Studies of numerous species have shown that a reduction in calories has been linked to a longer lifespan. The SIRT-1 gene activates a critical component of calorie restriction in mammals and promotes fat metabolization. There is evidence that resveratrol may be a calorie restriction mimetic, a compound that mimics the effects of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake, which may be helpful in promoting a longer lifespan. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting a healthy weight.*

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Primary Benefits:

·         Maintains cell health

·         Promotes normal cell cycle activity

·         Promotes apoptosis (programmed cell death) in unhealthy cells

·         Promotes normal nuclear factor kappa B (NF-Kappa B – protein) and cyclooxygenase-2 (COX-2 - enzyme) activity

·         Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)

·         Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles).

·         Superior antioxidant and high ORAC value

Vitamins Promoting Healthy Aging

People do not realize what vitamins can do for them. Vitamins are great for those who need them. On the other hand, if you have sufficient vitamins, then you will not need regimens of vitamins. Building vitamins in your system, which has too much already, or sufficient nutrients can cause harm. Vitamins will make you look younger and feel younger as well as make you feel good about yourself, providing you need regimens suited for your system.

How do I learn what vitamins are good for me?

We get natural vitamins in the foods we eat. Some times, you do not get the right amount so you have to take vitamins, which come in many ways. You can get them in a pill form, liquid, powder, etc. If the vitamins you choose do not work for you, your doctor can give you a shot. You can get almost all the vitamins you may need at local drug stores. You will find vitamins at supermarkets, department stores and so on. If you cannot determine which vitamins are right for you, check with your doctor. He may have some recommendations. In fact, you should visit your family doctor first and ask him/her, which vitamins may be suitable for your body type.

How vitamins help you:

Taking vitamins will help you to relieve stress. Vitamins will help control your weight, and help keep you from getting sick with the common cold and the flu. There are many vitamins to help you out. You can check out at your local pharmacy many different kinds. You pharmacist is your best friend as well as your doctor. He/she may be able to help you find out which vitamins are best suited for your body type.

What kinds of vitamins should I consider and for what purpose?

You have a wide array of vitamins to choose from, including B1, B12, B6, E, D, K, A, and so on. B1 is designed to help your heart function in order. The vitamin will assist your central nervous system as well, helping you to have a better attitude in life. B1 will give you energy, since it is known to swap blood sugar, transferring it to energy. B1 promotes a healthy mucous membrane, and will promote the muscular and cardio functions.

How to decide if you need vitamins:

Some things that you may feel if you are low on vitamins are fatigue. You may feel muscle tenderness, or experience insomnia. Insomnia can benefit from Melatonin supplements. You can get natural vitamins from corn breads, nuts, oatmeal, cereal, wheat and so on. Eat plenty of veggies and fruits also to get the vitamins you need.

If you have colds, you can benefit from Vitamin C. If you are searching for anti-aging vitamins consider E, since According to experts, Vitamin E is responsible for preserving oxygen in the blood, reduce more than 40% of the oxygen amount the heart needs as well. Vitamin E also has been linked to influential anti-coagulants. Some experts believe the vitamin will slow blood clotting by dilating the blood vessels. If you searching for the vitamin to help you stay young and healthy, then Vitamin E that contains 200 units is for you. 

According to German experts Wolf and Luczak Vitamin E is a stabilizer for youth and strong blood. If this is true, then dying cells will be replaced quickly by new cells. Dying cells is responsible for many diseases, including cancer, AIDS, HIV, leukemia and so on. In fact, T-Cells that deteriorate is responsible for AIDS, certain types of cancers, herpes simplex, and so on.

Healthy Aging with Vitamin and Supplements

The aging progression in our bodies is an on going thing each day of our lives. Bringing the clock to a standstill is out of the questions so we need to take care of ourselves on a daily basis. It is a known fact that as we age we need a dietary supplements and vitamins to substitute the declining bodily chemicals and substances.

Dietary supplements are sometimes needed because as we age our diets change and we eat less. Sometimes we eat more. As our skin and digestive system starts to change, so do our vitamin levels. In order to keep these levels up we may need to take a supplement to bring that level up where it belongs to keep us happy and healthy as we age.

Not having the right vitamins can cause cancers and chronic diseases to develop. We all need to understand the vitamins that we need and how they will help keep us stay healthy and safe. In all, we have two different kinds of vitamins, which one is the fat-soluble [A, D, E, K] and the second one is the water-soluble [B, C, P].

The fat-soluble vitamins if taken too much of can turn into a poison toxic. Our bodies produce Vitamin D and K, and the vitamins A and E need to come from our food or a supplement to help prevent cardiac disease and some cancers. Therefore, it is very important that you have the right amount of A, C, and E.

The water-soluble vitamins help the kidneys to rid of our excess waste on a daily basis so it is very important to get the right amount daily. You should consult with your physician to learn which vitamins and supplements are best suited for you.

TIP: CHIRO-KLEENZ is a healthy, natural herb tea that detoxifies and trims the system. It is designed for both men and women. NOTE: This tea will cleanse the body of poisons, yet you should note that the tea would cause cramping, and frequent bowel movement.

As we get older, our diets change and we don’t eat like we should. In addition, the foods we buy sometimes don’t have all or enough vitamins in them. The farmers are putting fertilizer and chemicals to make their crop larger and better and with all these chemicals, it lowers the vitamins that you get from your diet. Not eating the right diet or not enough can cause your vitamin level to drop. Some things you need to know are that Vitamin D is produced from the sun and the older we get the less we are outside, so by taking vitamin D it can help the brittle bones in our body and make them stronger.

You can find B-12 by eating the right lean red meats, chicken and drinking skim milk.  Taking Vitamin B-12 and B-6 it helps to reduce heart disease. B-12 will help the red blood cells produce and maintain the nervous system as well too.

Are you not taking vitamins because it is too hard to swallow them? 

Some of us as we get older have a hard time swallowing, stay healthy by buying liquid vitamins. If you are not sure what ones come in liquid form ask your doctor and he can help you decide what you need and tell you if they are in liquid form or not. Some pills can’t be cut up or crushed because they lose their strength, so stay healthy and look for the liquid type.

One of the most important things about healthy aging is to have a well balance meal three times a day. Take your medications and vitamin everyday as your doctor has prescribed and enjoy life.

Vitamins and minerals can be absorbed by the body in a number of ways. They first enter our body through the food we eat. Secondly, we can take vitamin supplements to increase the amount of pertinent vitamins and minerals. There are different methods of taking medication and one of the most common methods is absorbing it in its liquid form. Do the advantages of liquid vitamins far outweigh its disadvantages – if there are any? Read on and find out.

Better or Easier Absorption for Kids

Although liquid vitamins may taste worse than vitamins in flavored, chewable tablet forms, they are however easier to absorb. There are numerous cases in which children have problems with choking, breathing and swallowing simply because of their inability to absorb medication or vitamins in this form.

This is the same problem as well for adults who have lost their ability to control their jaws or are unable to digest anything that is not in liquid form.

Liquid Vitamins are More Effective

Because of its form, liquid vitamins can be assimilated immediately into the blood stream for a more systemic administration of the vitamin and its average absorption rate is approximately 90 to 98%. It is also three to five times more concentrated than vitamin pills and this lead to higher bio-activity and greater therapeutic benefits.

The Link between Antioxidants and Liquid Vitamins

Have you ever wondered whether or not liquid vitamins contained oxidants as well? Vitamins E, C and A are examples of antioxidants and they are commonly found in vitamin supplements but what about liquid vitamins?

And the answer is an absolute YES. Liquid vitamins must in fact contain such antioxidants or they’ll prove to be ineffective compared to other vitamins. Remember that the most important of all antioxidants – Vitamins A, C and E – are not internally produced by the body so they must be a regular fixture in our diet. Antioxidants are our main defense against effects of damaging oxidation reactions. Antioxidants are our best weapons against suffering from any form of cancer. Without it, we are basically weaker and less healthy.

Liquid Vitamins versus Digestive Acids

One reason why people refuse to acknowledge the benefits of liquid vitamins is because of the supposed destruction by digestive acids of any vitamin or mineral that it does not recognize as part of the process of digestion. The opposite is, in fact true. Our digestive system actually prefers or is able to better absorb liquid vitamins and minerals rather than those made in pill or capsule form.

A vitamin pill or tablet has to be digested completely before it can benefit the human body. It must be broken down into absorbable nutrients or only up to thirty percent of it will be absorbed by the human body. Liquid vitamins however provide a better and easier solution for the digestive system. Because it does not depend in any way on mechanical digestion, an estimated 90% of it can be absorbed directly by the body.

It’s vital to remember that digestion does not mainly function to destroy vitamins and minerals but rather to transform them into substances it can use to improve the general constitution of the body.

Liquid Vitamins: Toxic or Not?

Another problem posed is the amount of colloidal minerals found in liquid vitamins. Are they harmful or not?

In truth, even plants and fruits contain a trace of such minerals in them. Apples, for instance, contain 3-5 mg of aluminum as it’s one of the most abundant elements that can be found in the surface of the Earth. But do you hear anyone telling you that apples are dangerous to your health? On the contrary, what we are more likely to hear is that an apple a day keeps the doctor away.

And so it must be with liquid vitamins as well. Containing a slight amount of colloidal mineral doesn’t mean it’s bad for our health right away. Colloidal minerals, are above all else, naturally occurring elements and can not therefore be avoided.

You Have a Choice

At the end of the day, however, it’s still up to you whether or not you wish to take vitamin supplements in liquid or solid form. What really matters is what you prefer and which will ultimately work better for you.